Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer

Tumor hypoxia is associated with poor patient outcomes in estrogen receptor-α–positive (ERα(+)) breast cancer. Hypoxia is known to affect tumor growth by reprogramming metabolism and regulating amino acid (AA) uptake. Here, we show that the glutamine transporter, SNAT2, is the AA transporter most fr...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Morotti, Matteo, Bridges, Esther, Valli, Alessandro, Choudhry, Hani, Sheldon, Helen, Wigfield, Simon, Gray, Nicki, Zois, Christos E., Grimm, Fiona, Jones, Dylan, Teoh, Eugene J., Cheng, Wei-Chen, Lord, Simon, Anastasiou, Dimitrios, Haider, Syed, McIntyre, Alan, Goberdhan, Deborah C. I., Buffa, Francesca, Harris, Adrian L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589752/
https://ncbi.nlm.nih.gov/pubmed/31152137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818521116
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