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Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells

Many cancer cells depend on glutamine as they use the glutaminolysis pathway to generate building blocks and energy for anabolic purposes. As a result, glutamine transporters are essential for cancer growth and are potential targets for cancer chemotherapy with ASCT2 (SLC1A5) being investigated most...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Bröer, Angelika, Rahimi, Farid, Bröer, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933233/
https://ncbi.nlm.nih.gov/pubmed/27129276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.700534
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