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Tristetraprolin-mediated hexokinase 2 expression regulation contributes to glycolysis in cancer cells
Hexokinase 2 (HK2) catalyzes the first step of glycolysis and is up-regulated in cancer cells. The mechanism has not been fully elucidated. Tristetraprolin (TTP) is an AU-rich element (ARE)-binding protein that inhibits the expression of ARE-containing genes by enhancing mRNA degradation. TTP expres...
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| Veröffentlicht in: | Mol Biol Cell |
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| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society for Cell Biology
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6589696/ https://ncbi.nlm.nih.gov/pubmed/30650008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-09-0606 |
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