Tristetraprolin-mediated hexokinase 2 expression regulation contributes to glycolysis in cancer cells

Hexokinase 2 (HK2) catalyzes the first step of glycolysis and is up-regulated in cancer cells. The mechanism has not been fully elucidated. Tristetraprolin (TTP) is an AU-rich element (ARE)-binding protein that inhibits the expression of ARE-containing genes by enhancing mRNA degradation. TTP expres...

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Publicado no:Mol Biol Cell
Main Authors: Kim, Dong Jun, Vo, Mai-Tram, Choi, Seong Hee, Lee, Ji-Heon, Jeong, So Yeon, Hong, Chung Hwan, Kim, Jong Soo, Lee, Unn Hwa, Chung, Hyung-Min, Lee, Byung Ju, Cho, Wha Ja, Park, Jeong Woo
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589696/
https://ncbi.nlm.nih.gov/pubmed/30650008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-09-0606
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