CCR5 is a required signaling receptor for macrophage expression of inflammatory genes in response to viral double-stranded RNA

Double-stranded (ds) RNA, both synthetic and produced during virus replication, rapidly stimulates MAPK and NF-κB signaling that results in expression of the inflammatory genes inducible nitric oxide synthase, cyclooxygenase 2, and IL-1β by macrophages. Using biochemical and genetic approaches, we h...

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Bibliografiske detaljer
Udgivet i:Am J Physiol Regul Integr Comp Physiol
Main Authors: Shaheen, Zachary R., Christmann, Benjamin S., Stafford, Joshua D., Moran, Jason M., Buller, R. Mark L., Corbett, John A.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589596/
https://ncbi.nlm.nih.gov/pubmed/30811246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00019.2019
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