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CCR5 is a required signaling receptor for macrophage expression of inflammatory genes in response to viral double-stranded RNA
Double-stranded (ds) RNA, both synthetic and produced during virus replication, rapidly stimulates MAPK and NF-κB signaling that results in expression of the inflammatory genes inducible nitric oxide synthase, cyclooxygenase 2, and IL-1β by macrophages. Using biochemical and genetic approaches, we h...
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| Publicado no: | Am J Physiol Regul Integr Comp Physiol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6589596/ https://ncbi.nlm.nih.gov/pubmed/30811246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00019.2019 |
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