Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain (C1C2) Attenuates Deleterious Effects of Pressure Overload

A fusion protein (C1C2) constructed by fusing the intracellular C1 and C2 segments of adenylyl cyclase type 6 (AC6) retains beneficial effects of AC6 expression, without increasing cyclic adenosine monophosphate generation. The effects of cardiac-directed C1C2 expression in pressure overload is unkn...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther
Main Authors: Tan, Zhen, Giamouridis, Dimosthenis, Lai, N. Chin, Kim, Young Chul, Guo, Tracy, Xia, Bing, Gao, Mei Hua, Hammond, H. Kirk
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589496/
https://ncbi.nlm.nih.gov/pubmed/30638074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2018.176
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