Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain Reverses Cardiac Dysfunction Caused by Sustained Beta-Adrenergic Receptor Stimulation

Transgenic mice with cardiac-directed C1C2, a fusion protein of the intracellular C1 and C2 segments of adenylyl cyclase type 6, had normal left ventricular (LV) function, but diminished cAMP generation. Cardiac myocytes from C1C2 mice showed increased Ca(2+) release. Mice underwent continuous isopr...

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Dettagli Bibliografici
Pubblicato in:JACC Basic Transl Sci
Autori principali: Gao, Mei Hua, Lai, N. Chin, Giamouridis, Dimosthenis, Kim, Young Chul, Tan, Zhen, Guo, Tracy, Dillmann, Wolfgang H., Suarez, Jorge, Hammond, H. Kirk
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2016
Soggetti:
PRECLINICAL RESEARCH
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490496/
https://ncbi.nlm.nih.gov/pubmed/28670631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2016.08.004
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