Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain Reverses Cardiac Dysfunction Caused by Sustained Beta-Adrenergic Receptor Stimulation

Transgenic mice with cardiac-directed C1C2, a fusion protein of the intracellular C1 and C2 segments of adenylyl cyclase type 6, had normal left ventricular (LV) function, but diminished cAMP generation. Cardiac myocytes from C1C2 mice showed increased Ca(2+) release. Mice underwent continuous isopr...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:JACC Basic Transl Sci
Main Authors: Gao, Mei Hua, Lai, N. Chin, Giamouridis, Dimosthenis, Kim, Young Chul, Tan, Zhen, Guo, Tracy, Dillmann, Wolfgang H., Suarez, Jorge, Hammond, H. Kirk
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
PRECLINICAL RESEARCH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490496/
https://ncbi.nlm.nih.gov/pubmed/28670631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2016.08.004
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados