Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain Reverses Cardiac Dysfunction Caused by Sustained Beta-Adrenergic Receptor Stimulation

Transgenic mice with cardiac-directed C1C2, a fusion protein of the intracellular C1 and C2 segments of adenylyl cyclase type 6, had normal left ventricular (LV) function, but diminished cAMP generation. Cardiac myocytes from C1C2 mice showed increased Ca(2+) release. Mice underwent continuous isopr...

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Detalles Bibliográficos
Publicado en:JACC Basic Transl Sci
Autores principales: Gao, Mei Hua, Lai, N. Chin, Giamouridis, Dimosthenis, Kim, Young Chul, Tan, Zhen, Guo, Tracy, Dillmann, Wolfgang H., Suarez, Jorge, Hammond, H. Kirk
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2016
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490496/
https://ncbi.nlm.nih.gov/pubmed/28670631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2016.08.004
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