Adenylyl Cyclase 6 Deletion Increases Mortality During Sustained β-Adrenergic Receptor Stimulation

Sustained β-adrenergic receptor stimulation is associated with cardiomyopathy, an affect thought to result from cAMP-associated cardiac injury. Using a murine line with adenylyl cyclase 6 gene deletion (AC6KO), we tested the hypothesis that AC6 deletion, by limiting cAMP production, would attenuate...

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Главные авторы: Tang, Tong, Lai, N. Chin, Wright, Adam T., Gao, Mei Hua, Lee, Paul, Guo, Tracy, Tang, Ruoying, McCulloch, Andrew D., Hammond, H. Kirk
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987812/
https://ncbi.nlm.nih.gov/pubmed/23587598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2013.04.005
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