Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain Reverses Cardiac Dysfunction Caused by Sustained Beta-Adrenergic Receptor Stimulation

Transgenic mice with cardiac-directed C1C2, a fusion protein of the intracellular C1 and C2 segments of adenylyl cyclase type 6, had normal left ventricular (LV) function, but diminished cAMP generation. Cardiac myocytes from C1C2 mice showed increased Ca(2+) release. Mice underwent continuous isopr...

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Detaylı Bibliyografya
Yayımlandı:JACC Basic Transl Sci
Asıl Yazarlar: Gao, Mei Hua, Lai, N. Chin, Giamouridis, Dimosthenis, Kim, Young Chul, Tan, Zhen, Guo, Tracy, Dillmann, Wolfgang H., Suarez, Jorge, Hammond, H. Kirk
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2016
Konular:
PRECLINICAL RESEARCH
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490496/
https://ncbi.nlm.nih.gov/pubmed/28670631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2016.08.004
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