Activation of the mGlu(1) metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M(4) muscarinic receptor allosteric modulators

Recent clinical and preclinical studies suggest that selective activators of the M(4) muscarinic acetylcholine receptor have potential as a novel treatment for schizophrenia. M(4) activation inhibits striatal dopamine release by mobilizing endocannabinoids, providing a mechanism for local effects on...

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Publicado en:Mol Psychiatry
Autores principales: Yohn, Samantha E., Foster, Daniel J., Covey, Dan P., Moehle, Mark S., Galbraith, Jordan, Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Bubser, Michael, Blobaum, Anna L., Joffe, Max E., Cheer, Joseph F., Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588501/
https://ncbi.nlm.nih.gov/pubmed/30116027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-018-0206-2
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