Activation of the mGlu(1) metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M(4) muscarinic receptor allosteric modulators

Recent clinical and preclinical studies suggest that selective activators of the M(4) muscarinic acetylcholine receptor have potential as a novel treatment for schizophrenia. M(4) activation inhibits striatal dopamine release by mobilizing endocannabinoids, providing a mechanism for local effects on...

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Detaylı Bibliyografya
Yayımlandı:Mol Psychiatry
Asıl Yazarlar: Yohn, Samantha E., Foster, Daniel J., Covey, Dan P., Moehle, Mark S., Galbraith, Jordan, Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Bubser, Michael, Blobaum, Anna L., Joffe, Max E., Cheer, Joseph F., Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588501/
https://ncbi.nlm.nih.gov/pubmed/30116027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-018-0206-2
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