Activation of the mGlu(1) metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M(4) muscarinic receptor allosteric modulators

Recent clinical and preclinical studies suggest that selective activators of the M(4) muscarinic acetylcholine receptor have potential as a novel treatment for schizophrenia. M(4) activation inhibits striatal dopamine release by mobilizing endocannabinoids, providing a mechanism for local effects on...

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Bibliographic Details
Published in:Mol Psychiatry
Main Authors: Yohn, Samantha E., Foster, Daniel J., Covey, Dan P., Moehle, Mark S., Galbraith, Jordan, Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Bubser, Michael, Blobaum, Anna L., Joffe, Max E., Cheer, Joseph F., Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588501/
https://ncbi.nlm.nih.gov/pubmed/30116027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-018-0206-2
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