T227. THE METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 1 REGULATES STRIATAL DOPAMINE RELEASE VIA AN ENDOCANNABINOID-DEPENDENT MECHANISM: IMPLICATIONS FOR THE TREATMENT OF SCHIZOPHRENIA

BACKGROUND: Clinical and preclinical studies suggest that selective activators of the muscarinic M4 receptor have exciting potential as a novel approach for treatment of schizophrenia. M4 reduces striatal dopamine (DA) though release of endocannabinoids (eCB), providing a mechanism for local effects...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Schizophr Bull
Main Authors: Yohn, Samantha, Covey, Daniel, Foster, Daniel, Moehle, Mark, Galbraith, Jordan, Cheer, Joseph, Lindsley, Craig, Jeffrey Conn, P
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Abstracts
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5887981/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/schbul/sby016.503
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados