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Genetic Suppression of IKK2/NF-κB in Astrocytes Inhibits Neuroinflammation and Reduces Neuronal Loss in the MPTP-Probenecid Model of Parkinson’s Disease

Neuroinflammatory activation of glia is considered a pathological hallmark of Parkinson’s disease (PD) and is seen in both human PD patients and in animal models of PD; however, the relative contributions of these cell types, especially astrocytes, to the progression of disease is not fully understo...

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Bibliografiske detaljer
Udgivet i:Neurobiol Dis
Main Authors: Kirkley, Kelly S., Popichak, Katriana A., Hammond, Sean L., Davies, Cecilia, Hunt, Lindsay, Tjalkens, Ronald B.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588478/
https://ncbi.nlm.nih.gov/pubmed/30818064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.02.020
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