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The Nurr1 Ligand,1,1-bis(3′-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism

The orphan nuclear receptor Nurr1 (also called nuclear receptor-4A2) regulates inflammatory gene expression in glial cells, as well as genes associated with homeostatic and trophic function in dopaminergic neurons. Despite these known functions of Nurr1, an endogenous ligand has not been discovered....

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Dades bibliogràfiques
Publicat a:J Pharmacol Exp Ther
Autors principals: Hammond, Sean L., Popichak, Katriana A., Li, Xi, Hunt, Lindsay G., Richman, Evan H., Damale, Pranav U., Chong, Edwin K. P., Backos, Donald S., Safe, Stephen, Tjalkens, Ronald B.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5941193/
https://ncbi.nlm.nih.gov/pubmed/29626009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.246389
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