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The Nurr1 Ligand,1,1-bis(3′-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism

The orphan nuclear receptor Nurr1 (also called nuclear receptor-4A2) regulates inflammatory gene expression in glial cells, as well as genes associated with homeostatic and trophic function in dopaminergic neurons. Despite these known functions of Nurr1, an endogenous ligand has not been discovered....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Pharmacol Exp Ther
Egile Nagusiak: Hammond, Sean L., Popichak, Katriana A., Li, Xi, Hunt, Lindsay G., Richman, Evan H., Damale, Pranav U., Chong, Edwin K. P., Backos, Donald S., Safe, Stephen, Tjalkens, Ronald B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Pharmacology and Experimental Therapeutics 2018
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5941193/
https://ncbi.nlm.nih.gov/pubmed/29626009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.246389
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