The Nurr1 Ligand,1,1-bis(3′-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism

The orphan nuclear receptor Nurr1 (also called nuclear receptor-4A2) regulates inflammatory gene expression in glial cells, as well as genes associated with homeostatic and trophic function in dopaminergic neurons. Despite these known functions of Nurr1, an endogenous ligand has not been discovered....

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Hammond, Sean L., Popichak, Katriana A., Li, Xi, Hunt, Lindsay G., Richman, Evan H., Damale, Pranav U., Chong, Edwin K. P., Backos, Donald S., Safe, Stephen, Tjalkens, Ronald B.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
Assuntos:
Neuropharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5941193/
https://ncbi.nlm.nih.gov/pubmed/29626009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.246389
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