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AKAP95 organizes a nuclear microdomain to control local cAMP for regulating nuclear PKA
Contrary to the classic model of PKA residing outside of the nucleus, we identify a nuclear signaling complex that consists of AKAP95, PKA, and PDE4D5 and show that it forms a functional cAMP signaling microdomain. Locally generated cAMP can accumulate within the vicinity of this complex; but when c...
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| Published in: | Cell Chem Biol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6588460/ https://ncbi.nlm.nih.gov/pubmed/30982750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.03.003 |
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