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AKAP95 organizes a nuclear microdomain to control local cAMP for regulating nuclear PKA

Contrary to the classic model of PKA residing outside of the nucleus, we identify a nuclear signaling complex that consists of AKAP95, PKA, and PDE4D5 and show that it forms a functional cAMP signaling microdomain. Locally generated cAMP can accumulate within the vicinity of this complex; but when c...

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Bibliografische gegevens
Gepubliceerd in:Cell Chem Biol
Hoofdauteurs: Clister, Terri, Greenwald, Eric C., Baillie, George S., Zhang, Jin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588460/
https://ncbi.nlm.nih.gov/pubmed/30982750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.03.003
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