The UPR-PERK pathway is not a promising therapeutic target for mutant SOD1-induced ALS

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, characterized by motor neuron death in the brain and spinal cord. Mutations in the Cu/Zn superoxide dismutase (SOD1) gene account for ~20% of all familial ALS forms, corresponding to 1%–2% of all ALS cases. One of the su...

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Bibliografiske detaljer
Udgivet i:Neurobiol Dis
Main Authors: Dzhashiashvili, Yulia, Monckton, Chase P., Shah, Harini S., Kunjamma, Rejani B., Popko, Brian
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588429/
https://ncbi.nlm.nih.gov/pubmed/30923003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.03.024
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