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The UPR-PERK pathway is not a promising therapeutic target for mutant SOD1-induced ALS
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, characterized by motor neuron death in the brain and spinal cord. Mutations in the Cu/Zn superoxide dismutase (SOD1) gene account for ~20% of all familial ALS forms, corresponding to 1%–2% of all ALS cases. One of the su...
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| Publicado no: | Neurobiol Dis |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6588429/ https://ncbi.nlm.nih.gov/pubmed/30923003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.03.024 |
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