Activation of hedgehog signaling associates with early disease progression in chronic lymphocytic leukemia

Targeted sequencing of 103 leukemia-associated genes in leukemia cells from 841 treatment-naive patients with chronic lymphocytic leukemia (CLL) identified 89 (11%) patients as having CLL cells with mutations in genes encoding proteins that putatively are involved in hedgehog (Hh) signaling. Consist...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Ghia, Emanuela M., Rassenti, Laura Z., Neuberg, Donna S., Blanco, Alejandro, Yousif, Fouad, Smith, Erin N., McPherson, John D., Hudson, Thomas J., Harismendy, Olivier, Frazer, Kelly A., Kipps, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587306/
https://ncbi.nlm.nih.gov/pubmed/30923040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-09-873695
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