O-GlcNAc modification of Sox2 regulates self-renewal in pancreatic cancer by promoting its stability

Pancreatic adenocarcinoma (PDAC) claims more than 90% of the patients diagnosed with the disease owing to its aggressive biology that is manifested by high rate of tumor recurrence. Aberrant upregulation in the transcriptional activity of proteins involved in self-renewal like Sox2, Oct4 and Nanog i...

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Veröffentlicht in:Theranostics
Hauptverfasser: Sharma, Nikita S, Gupta, Vineet K, Dauer, Patricia, Kesh, Kousik, Hadad, Roey, Giri, Bhuwan, Chandra, Anjali, Dudeja, Vikas, Slawson, Chad, Banerjee, Santanu, Vickers, Selwyn M, Saluja, Ashok, Banerjee, Sulagna
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587167/
https://ncbi.nlm.nih.gov/pubmed/31281487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.32615
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