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Molecular basis for high affinity agonist binding in GPCRs
G protein-coupled receptors (GPCRs) in the G protein-coupled active state have higher affinity for agonists compared to when they are in the inactive state, but the molecular basis for this is unclear. We have determined four active-state structures of the β(1)-adrenoceptor (β(1)AR) bound to conform...
Guardat en:
| Publicat a: | Science |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6586556/ https://ncbi.nlm.nih.gov/pubmed/31072904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aau5595 |
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