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Crystal Structures of a Stabilized β(1)-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol

The β(1)-adrenoceptor (β(1)AR) is the site of action of beta blockers used in the treatment of cardiac-related illnesses. Two beta blockers, carvedilol and bucindolol, show distinctive activities compared to other beta blockers and have been proposed as treatments tailored to the Arg/Gly389(8.56) po...

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Detalhes bibliográficos
Main Authors: Warne, Tony, Edwards, Patricia C., Leslie, Andrew G.W., Tate, Christopher G.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384003/
https://ncbi.nlm.nih.gov/pubmed/22579251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.03.014
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