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Molecular Determinants of CGS21680 Binding to the Human Adenosine A(2A) Receptor

The adenosine A(2A) receptor (A(2A)R) plays a key role in transmembrane signaling mediated by the endogenous agonist adenosine. Here, we describe the crystal structure of human A(2A)R thermostabilized in an active-like conformation bound to the selective agonist 2-[p-(2-carboxyethyl)phenylethyl-amin...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Lebon, Guillaume, Edwards, Patricia C., Leslie, Andrew G. W., Tate, Christopher G.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720118/
https://ncbi.nlm.nih.gov/pubmed/25762024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.097360
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