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Molecular Determinants of CGS21680 Binding to the Human Adenosine A(2A) Receptor
The adenosine A(2A) receptor (A(2A)R) plays a key role in transmembrane signaling mediated by the endogenous agonist adenosine. Here, we describe the crystal structure of human A(2A)R thermostabilized in an active-like conformation bound to the selective agonist 2-[p-(2-carboxyethyl)phenylethyl-amin...
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| Yayımlandı: | Mol Pharmacol |
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| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4720118/ https://ncbi.nlm.nih.gov/pubmed/25762024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.097360 |
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