Binding of the prototypical adenosine A(2A) receptor agonist CGS 21680 to the cerebral cortex of adenosine A(1) and A(2A) receptor knockout mice

1. 2-p-(2-carboxyethylphenethylamino-5′-ethylcarboxamidoadenosine) (CGS 21680) is considered the reference compound to study adenosine A(2A) receptors. However, CGS 21680 binding in the cerebral cortex, where adenosine A(1) receptors are predominant, displays a mixed A(2A)/A(1) receptor pharmacology...

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Detalhes bibliográficos
Main Authors: Lopes, Luísa V, Halldner, Linda, Rebola, Nelson, Johansson, Björn, Ledent, Catherine, Chen, Jian Fan, Fredholm, Bertil B, Cunha, Rodrigo A
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574266/
https://ncbi.nlm.nih.gov/pubmed/14993095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705692
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