Inhibiting homologous recombination decreases extrachromosomal amplification but has no effect on intrachromosomal amplification in methotrexate‐resistant colon cancer cells

Gene amplification, which involves the two major topographical structures double minutes (DMs) and homegeneously stained region (HSR), is a common mechanism of treatment resistance in cancer and is initiated by DNA double‐strand breaks. NHEJ, one of DSB repair pathways, is involved in gene amplifica...

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Veröffentlicht in:Int J Cancer
Hauptverfasser: Cai, Mengdi, Zhang, Huishu, Hou, Liqing, Gao, Wei, Song, Ying, Cui, Xiaobo, Li, Chunxiang, Guan, Rongwei, Ma, Jinfa, Wang, Xu, Han, Yue, Lv, Yafan, Chen, Feng, Wang, Ping, Meng, Xiangning, Fu, Songbin
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Inc. 2018
Schlagworte:
Cancer Genetics and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586039/
https://ncbi.nlm.nih.gov/pubmed/30070702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.31781
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