Isocitrate Dehydrogenase Mutations in Glioma: From Basic Discovery to Therapeutics Development

Isocitrate dehydrogenase (IDH) is a key rate-limiting enzyme in the Krebs cycle that plays an important role in energy metabolism. In recent years, it has been found that IDH mutations are closely related to the occurrence and development of glioma, and it is a notable potential therapeutic target....

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Bibliographic Details
Published in:Front Oncol
Main Authors: Huang, Juan, Yu, Jialong, Tu, Lin, Huang, Nanqu, Li, Hang, Luo, Yong
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Oncology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6584818/
https://ncbi.nlm.nih.gov/pubmed/31263678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00506
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