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Isocitrate Dehydrogenase Mutations in Glioma: From Basic Discovery to Therapeutics Development
Isocitrate dehydrogenase (IDH) is a key rate-limiting enzyme in the Krebs cycle that plays an important role in energy metabolism. In recent years, it has been found that IDH mutations are closely related to the occurrence and development of glioma, and it is a notable potential therapeutic target....
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| Published in: | Front Oncol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Frontiers Media S.A.
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6584818/ https://ncbi.nlm.nih.gov/pubmed/31263678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00506 |
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