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Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers and therapeutic target
PURPOSE OF THE REVIEW: Isocitrate dehydrogenases, IDH1 and IDH2, decarboxylate isocitrate to α-ketoglutarate (α-KG), and reduce NADP to NADPH. Point mutations of IDH1 and IDH2 have been discovered in gliomas. IDH mutations cause loss of native enzymatic activities and confer novel activity of conver...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3640434/ https://ncbi.nlm.nih.gov/pubmed/22002076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WCO.0b013e32834cd415 |
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