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Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers and therapeutic target
PURPOSE OF THE REVIEW: Isocitrate dehydrogenases, IDH1 and IDH2, decarboxylate isocitrate to α-ketoglutarate (α-KG), and reduce NADP to NADPH. Point mutations of IDH1 and IDH2 have been discovered in gliomas. IDH mutations cause loss of native enzymatic activities and confer novel activity of conver...
Shranjeno v:
| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3640434/ https://ncbi.nlm.nih.gov/pubmed/22002076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WCO.0b013e32834cd415 |
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