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In silico analysis of PFN1 related to amyotrophic lateral sclerosis

Profilin 1 (PFN1) protein plays key roles in neuronal growth and differentiation, membrane trafficking, and regulation of the actin cytoskeleton. Four natural variants of PFN1 were described as related to ALS, the most common adult-onset motor neuron disorder. However, the pathological mechanism of...

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Bibliographic Details
Published in:PLoS One
Main Authors: Pereira, Gabriel Rodrigues Coutinho, Tellini, Giovanni Henrique Almeida Silva, De Mesquita, Joelma Freire
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6583998/
https://ncbi.nlm.nih.gov/pubmed/31216283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0215723
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