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10β,17α-Dihydroxyestra-1,4-dien-3-one: A bioprecursor prodrug preferentially producing 17α-estradiol in the brain for targeted neurotherapy
Uterotrophic effect of 17α-estradiol, the C17 epimer of the main human estrogen 17β-estradiol, was shown to manifest in animal models at doses lower than those necessary for central outcome raising concerns about its potential to treat maladies of the central nervous system. We introduce here 10β,17...
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| 出版年: | ACS Chem Neurosci |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6582959/ https://ncbi.nlm.nih.gov/pubmed/29843514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00184 |
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