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10β,17α-Dihydroxyestra-1,4-dien-3-one: A bioprecursor prodrug preferentially producing 17α-estradiol in the brain for targeted neurotherapy

Uterotrophic effect of 17α-estradiol, the C17 epimer of the main human estrogen 17β-estradiol, was shown to manifest in animal models at doses lower than those necessary for central outcome raising concerns about its potential to treat maladies of the central nervous system. We introduce here 10β,17...

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Publicado en:ACS Chem Neurosci
Autores principales: Prokai-Tatrai, Katalin, Nguyen, Vien, Prokai, Laszlo
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582959/
https://ncbi.nlm.nih.gov/pubmed/29843514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00184
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