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10β,17α-Dihydroxyestra-1,4-dien-3-one: A bioprecursor prodrug preferentially producing 17α-estradiol in the brain for targeted neurotherapy
Uterotrophic effect of 17α-estradiol, the C17 epimer of the main human estrogen 17β-estradiol, was shown to manifest in animal models at doses lower than those necessary for central outcome raising concerns about its potential to treat maladies of the central nervous system. We introduce here 10β,17...
שמור ב:
| הוצא לאור ב: | ACS Chem Neurosci |
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| Main Authors: | , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2018
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6582959/ https://ncbi.nlm.nih.gov/pubmed/29843514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00184 |
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