A novel potent ABCB1 modulator, phenethylisoquinoline alkaloid, reverses multidrug resistance in cancer cell

ATP-binding cassette (ABC) transporters, which are concerned with the efflux of anticancer drugs from cancer cells, have a pivotal role in multidrug resistance (MDR). In particular, ABCB1 is a well-known ABC transporter that develops MDR in many cancer cells. Some ABCB1 modulators can reverse ABCB1-...

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Publicado en:Mol Pharm
Autores principales: Sugisawa, Norihiko, Ohnuma, Shinobu, Ueda, Hirofumi, Murakami, Megumi, Sugiyama, Kyoko, Ohsawa, Kosuke, Kano, Kuniyuki, Tokuyama, Hidetoshi, Doi, Takayuki, Aoki, Junken, Ishida, Masaharu, Kudoh, Katsuyoshi, Naitoh, Takeshi, Ambudkar, Suresh V., Unno, Michiaki
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582940/
https://ncbi.nlm.nih.gov/pubmed/30052463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.8b00457
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