Scn2a Haploinsufficiency in Mice Suppresses Hippocampal Neuronal Excitability, Excitatory Synaptic Drive, and Long-Term Potentiation, and Spatial Learning and Memory

Nav1.2, a voltage-gated sodium channel subunit encoded by the Scn2a gene, has been implicated in various brain disorders, including epilepsy, autism spectrum disorder, intellectual disability, and schizophrenia. Nav1.2 is known to regulate the generation of action potentials in the axon initial segm...

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Dettagli Bibliografici
Pubblicato in:Front Mol Neurosci
Autori principali: Shin, Wangyong, Kweon, Hanseul, Kang, Ryeonghwa, Kim, Doyoun, Kim, Kyungdeok, Kang, Muwon, Kim, Seo Yeong, Hwang, Sun Nam, Kim, Jin Yong, Yang, Esther, Kim, Hyun, Kim, Eunjoon
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582764/
https://ncbi.nlm.nih.gov/pubmed/31249508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00145
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