Early correction of synaptic long-term depression improves abnormal anxiety-like behavior in adult GluN2B-C456Y-mutant mice

Extensive evidence links Glutamate receptor, ionotropic, NMDA2B (GRIN2B), encoding the GluN2B/NR2B subunit of N-methyl-D-aspartate receptors (NMDARs), with various neurodevelopmental disorders, including autism spectrum disorders (ASDs), but the underlying mechanisms remain unclear. In addition, it...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Shin, Wangyong, Kim, Kyungdeok, Serraz, Benjamin, Cho, Yi Sul, Kim, Doyoun, Kang, Muwon, Lee, Eun-Jae, Lee, Hyejin, Bae, Yong Chul, Paoletti, Pierre, Kim, Eunjoon
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7217483/
https://ncbi.nlm.nih.gov/pubmed/32353004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000717
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