Scn2a Haploinsufficiency in Mice Suppresses Hippocampal Neuronal Excitability, Excitatory Synaptic Drive, and Long-Term Potentiation, and Spatial Learning and Memory

Nav1.2, a voltage-gated sodium channel subunit encoded by the Scn2a gene, has been implicated in various brain disorders, including epilepsy, autism spectrum disorder, intellectual disability, and schizophrenia. Nav1.2 is known to regulate the generation of action potentials in the axon initial segm...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Shin, Wangyong, Kweon, Hanseul, Kang, Ryeonghwa, Kim, Doyoun, Kim, Kyungdeok, Kang, Muwon, Kim, Seo Yeong, Hwang, Sun Nam, Kim, Jin Yong, Yang, Esther, Kim, Hyun, Kim, Eunjoon
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582764/
https://ncbi.nlm.nih.gov/pubmed/31249508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00145
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