Scn2a Haploinsufficiency in Mice Suppresses Hippocampal Neuronal Excitability, Excitatory Synaptic Drive, and Long-Term Potentiation, and Spatial Learning and Memory

Nav1.2, a voltage-gated sodium channel subunit encoded by the Scn2a gene, has been implicated in various brain disorders, including epilepsy, autism spectrum disorder, intellectual disability, and schizophrenia. Nav1.2 is known to regulate the generation of action potentials in the axon initial segm...

Full description

Saved in:
Bibliographic Details
Published in:Front Mol Neurosci
Main Authors: Shin, Wangyong, Kweon, Hanseul, Kang, Ryeonghwa, Kim, Doyoun, Kim, Kyungdeok, Kang, Muwon, Kim, Seo Yeong, Hwang, Sun Nam, Kim, Jin Yong, Yang, Esther, Kim, Hyun, Kim, Eunjoon
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582764/
https://ncbi.nlm.nih.gov/pubmed/31249508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00145
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items