Discovery of a Potent, Long‐Acting, and CNS‐Active Inhibitor (BIA 10‐2474) of Fatty Acid Amide Hydrolase

Fatty acid amide hydrolase (FAAH) can be targeted for the treatment of pain associated with various medical conditions. Herein we report the design and synthesis of a novel series of heterocyclic‐N‐carboxamide FAAH inhibitors that have a good alignment of potency, metabolic stability and selectivity...

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Publicado no:ChemMedChem
Main Authors: Kiss, László E., Beliaev, Alexandre, Ferreira, Humberto S., Rosa, Carla P., Bonifácio, Maria João, Loureiro, Ana I., Pires, Nuno M., Palma, P. Nuno, Soares‐da‐Silva, Patrício
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582431/
https://ncbi.nlm.nih.gov/pubmed/30113139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800393
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