Rapid progression to AML in a patient with germline GATA2 mutation and acquired NRAS Q61K mutation

GATA2 deficiency syndrome is caused by autosomal dominant, heterozygous germline mutations with widespread effects on immune, pulmonary and vascular systems. Patients commonly develop hematological abnormalities including bone marrow failure, myelodysplastic syndrome (MDS) and acute myeloid leukemia...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Leuk Res Rep
Prif Awduron: McReynolds, Lisa J., Zhang, Yubo, Yang, Yanqin, Tang, Jingrong, Mulé, Matthew, Hsu, Amy P., Townsley, Danielle M., West, Robert R., Zhu, Jun, Hickstein, Dennis D., Holland, Steven M., Calvo, Katherine R., Hourigan, Christopher S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582196/
https://ncbi.nlm.nih.gov/pubmed/31245276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lrr.2019.100176
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