β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

Hypertrophic cardiomyopathy (HCM) affects 1 in 500 people and leads to hyper-contractility of the heart. Nearly 40 percent of HCM-causing mutations are found in human β-cardiac myosin. Previous studies looking at the effect of HCM mutations on the force, velocity and ATPase activity of the catalytic...

Full description

Saved in:
Bibliographic Details
Published in:Nat Commun
Main Authors: Adhikari, Arjun S., Trivedi, Darshan V., Sarkar, Saswata S., Song, Dan, Kooiker, Kristina B., Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582153/
https://ncbi.nlm.nih.gov/pubmed/31213605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10555-9
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items