Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy

Deciphering how TCR signals are modulated by coinhibitory receptors is of fundamental and clinical interest. Using quantitative interactomics, we define the composition and dynamics of the PD-1 and BTLA coinhibitory signalosomes in primary effector T cells and at the T cell-antigen-presenting cell i...

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Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Celis-Gutierrez, Javier, Blattmann, Peter, Zhai, Yunhao, Jarmuzynski, Nicolas, Ruminski, Kilian, Grégoire, Claude, Ounoughene, Youcef, Fiore, Frédéric, Aebersold, Ruedi, Roncagalli, Romain, Gstaiger, Matthias, Malissen, Bernard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cell Press 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581740/
https://ncbi.nlm.nih.gov/pubmed/31189114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.05.041
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