Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy

Deciphering how TCR signals are modulated by coinhibitory receptors is of fundamental and clinical interest. Using quantitative interactomics, we define the composition and dynamics of the PD-1 and BTLA coinhibitory signalosomes in primary effector T cells and at the T cell-antigen-presenting cell i...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Celis-Gutierrez, Javier, Blattmann, Peter, Zhai, Yunhao, Jarmuzynski, Nicolas, Ruminski, Kilian, Grégoire, Claude, Ounoughene, Youcef, Fiore, Frédéric, Aebersold, Ruedi, Roncagalli, Romain, Gstaiger, Matthias, Malissen, Bernard
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581740/
https://ncbi.nlm.nih.gov/pubmed/31189114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.05.041
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki