Quantitative proteomic analysis of signalosome dynamics in primary T cells identifies the CD6 surface receptor as a Lat-independent TCR signaling hub

T cell antigen receptor (TCR)-mediated T cell activation requires the interaction of dozens of proteins. We used quantitative mass spectrometry and activated primary CD4(+) T cells from mice in which a tag for affinity purification was knocked into several genes to determine the composition and dyna...

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Bibliografski detalji
Glavni autori: Roncagalli, Romain, Hauri, Simon, Fiore, Fréderic, Liang, Yinming, Chen, Zhi, Sansoni, Amandine, Kanduri, Kartiek, Joly, Rachel, Malzac, Aurélie, Lähdesmäki, Harri, Lahesmaa, Riitta, Yamasaki, Sho, Saito, Takashi, Malissen, Marie, Aebersold, Ruedi, Gstaiger, Matthias, Malissen, Bernard
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4037560/
https://ncbi.nlm.nih.gov/pubmed/24584089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2843
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