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CD25 and protein phosphatase 2A cooperate to enhance IL-2R signaling in human regulatory T cells

Low-dose IL-2 therapy is a direct approach to boost Tregs and promote immune tolerance in autoimmune patients. However, the mechanisms responsible for selective response of Tregs to low-dose IL-2 is not fully understood. Here we directly assessed the contribution of CD25 and protein phosphatase 2A (...

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Bibliografische gegevens
Gepubliceerd in:J Immunol
Hoofdauteurs: Ding, Ying, Yu, Aixin, Tsokos, George C., Malek, Thomas R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581624/
https://ncbi.nlm.nih.gov/pubmed/31085588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801570
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