IL-2/CD25: A long-acting fusion protein that promotes immune tolerance by selectively targeting the IL-2R on regulatory T cells

Low-dose IL-2 represents an immunotherapy to selectively expand regulatory T cells (Tregs) to promote tolerance in patients with autoimmunity. Here we show that a fusion protein (FP) of mouse IL-2 and mouse IL-2Rα (CD25), joined by a non-cleavable linker, has greater in vivo efficacy than recombinan...

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Vydáno v:J Immunol
Hlavní autoři: Ward, Natasha C., Yu, Aixin, Moro, Alejandro, Ban, Yuguang, Chen, Xi, Hsiung, Sunnie, Keegan, James, Arbanas, Jaren M., Loubeau, Martine, Thankappan, Anil, Yamniuk, Aaron P., Davis, Jonathan H., Struthers, Mary, Malek, Thomas R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6200646/
https://ncbi.nlm.nih.gov/pubmed/30282751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800907
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