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A low IL-2R signaling threshold supports the development and homeostasis of T regulatory cells
The IL-2/IL-2R interaction is essential for Treg cell development and homeostasis. Here we show that expression of IL-2Rβ chains that lack tyrosine residues important for the association of the adaptor Shc and STAT5 in IL-2Rβ-deficient mice resulted in production of a normal proportion of natural Tr...
Tallennettuna:
| Päätekijät: | , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2009
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2962446/ https://ncbi.nlm.nih.gov/pubmed/19185518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.11.014 |
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