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Synthesis of nucleoside analogs from hydrazine derivatives
Reaction of 6-hydrazino-l,3-dimethyluracil (1) with glycosyl isothiocyanates (2a,b,c) gave the glycosyl thiosemicarbazides (3a,b,c) in good yield, which were cyclized to pyrimidothiadiazines (5a,b,c) with NBS oxidation. And 5a,b,c were converted to pyrazolopyrimidines (6a,b,c) by thermal desulfuriza...
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| Publié dans: | Nucleic Acids Res |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
1978
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6581323/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/1.suppl_2.s251 |
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