Chain-Shortened Myostatin Inhibitory Peptides Improve Grip Strength in Mice

[Image: see text] Inhibition of myostatin is a promising strategy for treatment of muscle atrophic disorders. We had already identified a 23-mer peptide (1) as a synthetic myostatin inhibitor, and structure–activity relationship studies with 1 afforded a potent 22-mer peptide derivative (3). Herein,...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Takayama, Kentaro, Asari, Tomo, Saitoh, Mariko, Nirasawa, Kei, Sasaki, Eri, Roppongi, Yoshimi, Nakamura, Akari, Saga, Yusuke, Shimada, Takahiro, Ikeyama, Hiroaki, Taguchi, Akihiro, Taniguchi, Atsuhiko, Negishi, Yoichi, Hayashi, Yoshio
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2019
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580550/
https://ncbi.nlm.nih.gov/pubmed/31223459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00174
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