Development of Potent Myostatin Inhibitory Peptides through Hydrophobic Residue-Directed Structural Modification

[Image: see text] Myostatin, a negative regulator of skeletal muscle growth, is a promising target for treating muscle atrophic disorders. Recently, we discovered a minimal myostatin inhibitor 1 (WRQNTRYSRIEAIKIQILSKLRL-amide) derived from positions 21–43 of the mouse myostatin prodomain. We previou...

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Bibliografiske detaljer
Udgivet i:ACS Med Chem Lett
Main Authors: Takayama, Kentaro, Rentier, Cédric, Asari, Tomo, Nakamura, Akari, Saga, Yusuke, Shimada, Takahiro, Nirasawa, Kei, Sasaki, Eri, Muguruma, Kyohei, Taguchi, Akihiro, Taniguchi, Atsuhiko, Negishi, Yoichi, Hayashi, Yoshio
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2017
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512132/
https://ncbi.nlm.nih.gov/pubmed/28740611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00168
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