Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis

IMPORTANCE: Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number of neurological conditions compared with healthy controls (HC) and is a candidate biomarker for neuroaxonal damage. The influence of age and sex is largely unknown, and levels across neurological disor...

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Publicado en:JAMA Neurol
Autores principales: Bridel, Claire, van Wieringen, Wessel N., Zetterberg, Henrik, Tijms, Betty M., Teunissen, Charlotte E., Alvarez-Cermeño, José C., Andreasson, Ulf, Axelsson, Markus, Bäckström, David C., Bartos, Ales, Bjerke, Maria, Blennow, Kaj, Boxer, Adam, Brundin, Lou, Burman, Joachim, Christensen, Tove, Fialová, Lenká, Forsgren, Lars, Frederiksen, Jette L., Gisslén, Magnus, Gray, Elizabeth, Gunnarsson, Martin, Hall, Sara, Hansson, Oskar, Herbert, Megan K., Jakobsson, Joel, Jessen-Krut, Jan, Janelidze, Shorena, Johannsson, Gudmundur, Jonsson, Michael, Kappos, Ludwig, Khademi, Mohsen, Khalil, Michael, Kuhle, Jens, Landén, Mikael, Leinonen, Ville, Logroscino, Giancarlo, Lu, Ching-Hua, Lycke, Jan, Magdalinou, Nadia K., Malaspina, Andrea, Mattsson, Niklas, Meeter, Lieke H., Mehta, Sanjay R., Modvig, Signe, Olsson, Tomas, Paterson, Ross W., Pérez-Santiago, Josué, Piehl, Fredrik, Pijnenburg, Yolande A. L., Pyykkö, Okko T., Ragnarsson, Oskar, Rojas, Julio C., Romme Christensen, Jeppe, Sandberg, Linda, Scherling, Carole S., Schott, Jonathan M., Sellebjerg, Finn T., Simone, Isabella L., Skillbäck, Tobias, Stilund, Morten, Sundström, Peter, Svenningsson, Anders, Tortelli, Rosanna, Tortorella, Carla, Trentini, Alessandro, Troiano, Maria, Turner, Martin R., van Swieten, John C., Vågberg, Mattias, Verbeek, Marcel M., Villar, Luisa M., Visser, Pieter Jelle, Wallin, Anders, Weiss, Andreas, Wikkelsø, Carsten, Wild, Edward J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Medical Association 2019
Materias:
Original Investigation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580449/
https://ncbi.nlm.nih.gov/pubmed/31206160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2019.1534
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